Circadian rhythms, metabolic oscillators, and the target of rapamycin (TOR) pathway: the Neurospora connection.
Identifieur interne : 000373 ( Main/Exploration ); précédent : 000372; suivant : 000374Circadian rhythms, metabolic oscillators, and the target of rapamycin (TOR) pathway: the Neurospora connection.
Auteurs : Patricia Lakin-Thomas [Canada]Source :
- Current genetics [ 1432-0983 ] ; 2019.
Descripteurs français
- KwdFr :
- MESH :
- métabolisme : Sérine-thréonine kinases TOR.
- physiologie : Neurospora crassa, Rythme circadien.
- Horloges circadiennes, Métabolisme énergétique, Transduction du signal.
English descriptors
- KwdEn :
- MESH :
- chemical , metabolism : TOR Serine-Threonine Kinases.
- physiology : Circadian Rhythm, Neurospora crassa.
- Circadian Clocks, Energy Metabolism, Signal Transduction.
Abstract
Circadian (24-h) rhythmicity is a fundamental property of eukaryotic cells, and it is not surprising that it intersects with fundamental metabolic processes. Many links between these two processes have been documented, and speculation has been growing that there may be circadian "metabolic oscillators" that interact with and exist independently of the well-known circadian transcription/translation feedback loops (TTFLs) that have been extensively studied. This review takes a critical look at the evidence for the existence of metabolic oscillators at the cellular level, attempting to answer these questions: does metabolism affect circadian rhythmicity, and vice versa? Is metabolism rhythmic, and if so, is that rhythmicity cell autonomous? Systems displaying "non-canonical rhythmicity" in the absence of functional TTFLs provide opportunities for identifying metabolic oscillators, and this review emphasizes the fungus Neurospora crassa as a model system. Recent papers describing links between the target of rapamycin (TOR) signaling pathway and circadian rhythmicity are highlighted, suggesting the potential for TOR signaling in generating rhythmicity independent of TTFLs.
DOI: 10.1007/s00294-018-0897-6
PubMed: 30367189
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Circadian rhythms, metabolic oscillators, and the target of rapamycin (TOR) pathway: the Neurospora connection.</title><author><name sortKey="Lakin Thomas, Patricia" sort="Lakin Thomas, Patricia" uniqKey="Lakin Thomas P" first="Patricia" last="Lakin-Thomas">Patricia Lakin-Thomas</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biology, York University, Toronto, ON, M3J 1P3, Canada. plakin@yorku.ca.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Biology, York University, Toronto, ON, M3J 1P3</wicri:regionArea><wicri:noRegion>M3J 1P3</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2019">2019</date><idno type="RBID">pubmed:30367189</idno><idno type="pmid">30367189</idno><idno type="doi">10.1007/s00294-018-0897-6</idno><idno type="wicri:Area/Main/Corpus">000418</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000418</idno><idno type="wicri:Area/Main/Curation">000418</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000418</idno><idno type="wicri:Area/Main/Exploration">000418</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Circadian rhythms, metabolic oscillators, and the target of rapamycin (TOR) pathway: the Neurospora connection.</title><author><name sortKey="Lakin Thomas, Patricia" sort="Lakin Thomas, Patricia" uniqKey="Lakin Thomas P" first="Patricia" last="Lakin-Thomas">Patricia Lakin-Thomas</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biology, York University, Toronto, ON, M3J 1P3, Canada. plakin@yorku.ca.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Biology, York University, Toronto, ON, M3J 1P3</wicri:regionArea><wicri:noRegion>M3J 1P3</wicri:noRegion></affiliation></author></analytic><series><title level="j">Current genetics</title><idno type="eISSN">1432-0983</idno><imprint><date when="2019" type="published">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Circadian Clocks (MeSH)</term><term>Circadian Rhythm (physiology)</term><term>Energy Metabolism (MeSH)</term><term>Neurospora crassa (physiology)</term><term>Signal Transduction (MeSH)</term><term>TOR Serine-Threonine Kinases (metabolism)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Horloges circadiennes (MeSH)</term><term>Métabolisme énergétique (MeSH)</term><term>Neurospora crassa (physiologie)</term><term>Rythme circadien (physiologie)</term><term>Sérine-thréonine kinases TOR (métabolisme)</term><term>Transduction du signal (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>TOR Serine-Threonine Kinases</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Sérine-thréonine kinases TOR</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Neurospora crassa</term><term>Rythme circadien</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Circadian Rhythm</term><term>Neurospora crassa</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Circadian Clocks</term><term>Energy Metabolism</term><term>Signal Transduction</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Horloges circadiennes</term><term>Métabolisme énergétique</term><term>Transduction du signal</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Circadian (24-h) rhythmicity is a fundamental property of eukaryotic cells, and it is not surprising that it intersects with fundamental metabolic processes. Many links between these two processes have been documented, and speculation has been growing that there may be circadian "metabolic oscillators" that interact with and exist independently of the well-known circadian transcription/translation feedback loops (TTFLs) that have been extensively studied. This review takes a critical look at the evidence for the existence of metabolic oscillators at the cellular level, attempting to answer these questions: does metabolism affect circadian rhythmicity, and vice versa? Is metabolism rhythmic, and if so, is that rhythmicity cell autonomous? Systems displaying "non-canonical rhythmicity" in the absence of functional TTFLs provide opportunities for identifying metabolic oscillators, and this review emphasizes the fungus Neurospora crassa as a model system. Recent papers describing links between the target of rapamycin (TOR) signaling pathway and circadian rhythmicity are highlighted, suggesting the potential for TOR signaling in generating rhythmicity independent of TTFLs.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">30367189</PMID><DateCompleted><Year>2019</Year><Month>07</Month><Day>29</Day></DateCompleted><DateRevised><Year>2020</Year><Month>07</Month><Day>28</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1432-0983</ISSN><JournalIssue CitedMedium="Internet"><Volume>65</Volume><Issue>2</Issue><PubDate><Year>2019</Year><Month>Apr</Month></PubDate></JournalIssue><Title>Current genetics</Title><ISOAbbreviation>Curr Genet</ISOAbbreviation></Journal><ArticleTitle>Circadian rhythms, metabolic oscillators, and the target of rapamycin (TOR) pathway: the Neurospora connection.</ArticleTitle><Pagination><MedlinePgn>339-349</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1007/s00294-018-0897-6</ELocationID><Abstract><AbstractText>Circadian (24-h) rhythmicity is a fundamental property of eukaryotic cells, and it is not surprising that it intersects with fundamental metabolic processes. Many links between these two processes have been documented, and speculation has been growing that there may be circadian "metabolic oscillators" that interact with and exist independently of the well-known circadian transcription/translation feedback loops (TTFLs) that have been extensively studied. This review takes a critical look at the evidence for the existence of metabolic oscillators at the cellular level, attempting to answer these questions: does metabolism affect circadian rhythmicity, and vice versa? Is metabolism rhythmic, and if so, is that rhythmicity cell autonomous? Systems displaying "non-canonical rhythmicity" in the absence of functional TTFLs provide opportunities for identifying metabolic oscillators, and this review emphasizes the fungus Neurospora crassa as a model system. Recent papers describing links between the target of rapamycin (TOR) signaling pathway and circadian rhythmicity are highlighted, suggesting the potential for TOR signaling in generating rhythmicity independent of TTFLs.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Lakin-Thomas</LastName><ForeName>Patricia</ForeName><Initials>P</Initials><Identifier Source="ORCID">http://orcid.org/0000-0002-0545-9561</Identifier><AffiliationInfo><Affiliation>Department of Biology, York University, Toronto, ON, M3J 1P3, Canada. plakin@yorku.ca.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>2017-05664</GrantID><Agency>Natural Sciences and Engineering Research Council of Canada</Agency><Country></Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016454">Review</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2018</Year><Month>10</Month><Day>26</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Curr Genet</MedlineTA><NlmUniqueID>8004904</NlmUniqueID><ISSNLinking>0172-8083</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>EC 2.7.1.1</RegistryNumber><NameOfSubstance UI="D058570">TOR Serine-Threonine Kinases</NameOfSubstance></Chemical></ChemicalList><MeshHeadingList><MeshHeading><DescriptorName UI="D057906" MajorTopicYN="N">Circadian Clocks</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002940" MajorTopicYN="N">Circadian Rhythm</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004734" MajorTopicYN="Y">Energy Metabolism</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009492" MajorTopicYN="N">Neurospora crassa</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015398" MajorTopicYN="Y">Signal Transduction</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D058570" MajorTopicYN="N">TOR Serine-Threonine Kinases</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Circadian</Keyword><Keyword MajorTopicYN="N">Metabolism</Keyword><Keyword MajorTopicYN="N">Neurospora crassa</Keyword><Keyword MajorTopicYN="N">Oscillator</Keyword><Keyword MajorTopicYN="N">Target of rapamycin</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2018</Year><Month>09</Month><Day>03</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2018</Year><Month>10</Month><Day>20</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2018</Year><Month>10</Month><Day>09</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2018</Year><Month>10</Month><Day>28</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2019</Year><Month>7</Month><Day>30</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2018</Year><Month>10</Month><Day>28</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">30367189</ArticleId><ArticleId IdType="doi">10.1007/s00294-018-0897-6</ArticleId><ArticleId IdType="pii">10.1007/s00294-018-0897-6</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Canada</li></country></list><tree><country name="Canada"><noRegion><name sortKey="Lakin Thomas, Patricia" sort="Lakin Thomas, Patricia" uniqKey="Lakin Thomas P" first="Patricia" last="Lakin-Thomas">Patricia Lakin-Thomas</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Bois/explor/RapamycinFungusV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000373 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000373 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Bois
|area= RapamycinFungusV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:30367189
|texte= Circadian rhythms, metabolic oscillators, and the target of rapamycin (TOR) pathway: the Neurospora connection.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:30367189" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a RapamycinFungusV1
| This area was generated with Dilib version V0.6.38. |  |